The classic Christian anti-Semitism of the European countries began to take root in the Arab-Muslim World as a widespread phenomenon in the early twentieth century. Anti-Semitism in the Arab-Muslim World is generally directed at Israel as a Jewish-Zionist state and at the Jewish People that supports Israel, so that no clear distinction is made in the Arab-Muslim World between criticism of the State of Israel and incitement against the Jewish People. Anti-Semitism in the Arab-Muslim World is prominent in Iran, but it is also widespread among other Arab and Islamic regimes.

The de-legitimization campaign is a global campaign against Israel and the Jewish People that originated at the Durban conference in South Africa. Its goal is to brand Israel as a leper state and as an apartheid state in order to undermine its legitimacy and bring about its collapse, just as the apartheid regime in South Africa collapsed. Attempts to delegitimize Israel succeed in providing an ideological platform for promoting and leveraging a policy of sanctions, diversion of investments and boycotts in a wide range of areas such as academia, culture and sports, the economy, defense and more.

The de-legitimization campaign is also characterized by organized convoys and flotillas to the Gaza Strip, protest demonstrations, marches, events marking anniversaries, boycotting Israeli goods and more. The organizers of the de-legitimization events try to attract widespread media coverage and challenge Israel to respond to them.

To manage the de-legitimization campaign, organizations affiliated with radical Islam joined forces with extreme leftist organizations, human rights organizations, and NGOs from Western countries. The de-legitimization campaign is now characterized mainly by anti-Israeli activity in the West, together with the campaign to boycott Israel (BDS). In the past, the partners in the de-legitimization campaign carried out activities such as convoys and flotillas to Gaza/